I just started his newest book, Little Things, last night and it's very very good. I had to force myself to go to bed otherwise I could've flown through all 340odd pages in one sitting.
I'm not really a fan of the Change-Bots, but the autobiographical stuff is beautiful and Big Head, and I want to be Small are a lot of fun. The cat book is purrrfect as well. If you're a cat person anyway.

I think my favourite so far is Unlikely, the one about losing his virginity.

Any other fans of these nervous indie relationships, break-ups and observation comics?

http://www.margomitchell.com/thc/jb.htm
http://www.topshelfcomix.com/creators.php?artist=14